Ritalin (speed for kids) is over prescribed to say the least!
July 26, 2007
CHILDREN who use Ritalin for a
long period of time could be more at
risk of delinquency and
substance abuse,
a study has found.
Doctors are suggesting children
with attention deficit hyperactivity
disorder (ADHD) should take a
break from medication after
three years of use.
An American study –
published in the Medical Observer _
has found that while drugs such
as Ritalin can initially help sufferers,
the benefit of prolonged use
is in doubt.
Some children stay on medication
until they reach 18,
but researchers believe it
may not protect them from
all the symptoms.
The US Multimodal Treatment Study of Children revealed the more days of prescribed medication, the more serious delinquency became.
In a cohort of 500 children with ADHD – followed for 36 months until they were 12 – researchers found 27 per cent were at a greater risk of committing crime, compared with 7 per cent among “normative” children.
Substance use also increased to 17 per cent in ADHD children – almost double the normal rate.
More than 30,000 children in Australia take Ritalin or a similar drug.
Jill Sewell, Associate Professor of the Royal Australian College of Physicians, said evidence suggested a break from medication was beneficial.
“Evidence shows that there is very clear benefit of taking medication for 12-18 months, but after three years it is not so clear,” she said.
“Often in medications you do have to stop for a period of time to see if it is still effective.”
Belrose mother Leanne Komaromi said she took her son Dominic off Ritalin after four months.
“It made him a completely different person – it shut him down,” she said.
“It was like someone had drawn the blinds on him.”
Side effects
Some adverse effects may emerge during chronic use of methylphenidate so a constant watch for adverse effects is recommended.[47] Some adverse effects of stimulant therapy may emerge during long-term therapy, but there is very little research of the long-term effects of stimulants.[48][49] The most common side effects of methylphenidate are nervousness, drowsiness andinsomnia. Other adverse reactions include:[50]
- Abdominal pain
- Akathisia (restlessness)
- Alopecia (loss of hair)
- Angina (chest pain)
- Appetite loss
- Anxiety
- Blood pressure and pulse changes (both up and down)
- Cardiac arrhythmia
- Diaphoresis (sweating)
- Dizziness
- Dyskinesia
- Euphoria
- Headache
- Hypersensitivity (including skin rash, urticaria, fever, arthralgia, exfoliative dermatitis, erythema multiforme, necrotizing vasculitis, and thrombocytopenic purpura)
- Lethargy
- Libido increased or decreased
- Nausea
- Palpitations
- Pupil dilation[51]
- Psychosis and psychiatric disorders - stimulants above the recommended dose level are associated with higher levels of psychosis, substance misuse and psychiatric admissions.[52]
- Short-term weight loss
- Somnolence
- Stunted growth
- Tachycardia (rapid resting heart rate)
- Xerostomia (dry mouth)
On occasion, treatment emergent psychosis can occur during long-term therapy with methylphenidate. Stimulants such as methylphenidate should be avoided in people who have a vulnerability to schizophrenia or drug addiction; however, psychotic symptoms may emerge during therapy with methylphenidate in individuals without these risk factors; regular psychiatric monitoring of people who are taking methylphenidate for adverse effects such as psychotic symptomatology (with regard to the need for dose adjustment or discontinuation of medication) has been recommended.[5]
On March 22, 2006, the FDA Pediatric Advisory Committee decided that medications using methylphenidate ingredients do not need black box warnings about their risks, noting that "for normal children, these drugs do not appear to pose an obvious cardiovascular risk."[53] Previously, 19 possible cases had been reported of cardiac arrest linked to children taking methylphenidate[54] and the Drug Safety and Risk Management Advisory Committee to the FDA recommend a "black-box" warning in 2006 for stimulant drugs used to treat attention deficit/hyperactivity disorder.[55]
Historical concerns related to child growth and cancer risk have existed, and these are still monitored and studied, however current scientific consensus is that the evidence of studies suggests these are either dubious or low-significance risks. (See : Previous health concerns now considered doubtful or largely minor)
[edit]Long-term effects
It was documented in 2000, by Zito et al.[56] "that at least 1.5% of children between the ages of two and four are medicated with stimulants, anti-depressants and anti-psychotic drugs, despite the paucity of controlled scientific trials confirming safety and long-term effects with preschool children."
The effects of long-term methylphenidate treatment on the developing brains of children with ADHD is the subject of study and debate.[57][58] Although the safety profile of short-term methylphenidate therapy in clinical trials has been well established, repeated use of psychostimulants such as methylphenidate is less clear. There are no well defined withdrawal schedules for discontinuing long-term use of stimulants.[59] There is limited data that suggests there are benefits to long-term treatment in correctly diagnosed children with ADHD, with overall modest risks.[60]Short-term clinical trials lasting a few weeks show an incidence of psychosis of about 0.1%.[61] A small study of just under 100 children that assessed long-term outcome of stimulant use found that 6% of children became psychotic after months or years of stimulant therapy. Typically, psychosis would abate soon after stopping stimulant therapy. As the study size was small, larger studies have been recommended.[62] The long-term effects on mental health disorders in later life of chronic use of methylphenidate is unknown.[63] Concerns have been raised that long-term therapy might cause drug dependence, paranoia, schizophrenia and behavioral sensitisation, similar to other stimulants.[64] Psychotic symptoms from methylphenidate can include hearing voices,visual hallucinations, urges to harm oneself, severe anxiety, euphoria, grandiosity, paranoid delusions, confusion, increased aggression and irritability. Methylphenidate psychosis is unpredictable in whom it will occur. Family history of mental illness does not predict the incidence of stimulant toxicosis in children with ADHD. High rates of childhood stimulant use is found in patients with a diagnosis of schizophrenia and bipolar disorder independent of ADHD. Individuals with a diagnosis of bipolar or schizophrenia who were prescribed stimulants during childhood typically have a significantly earlier onset of the psychotic disorder and suffer a more severe clinical course of psychotic disorder.[65][66][67] Knowledge of the effects of chronic use of methylphenidate is poorly understood with regard to persisting behavioral and neuroadaptational effects.[68]
Tolerance and behavioural sensitisation may occur with long-term use of methylphenidate.[69] There is also cross tolerance with other stimulants such as amphetamines and cocaine.[70] Stimulantwithdrawal or rebound reactions can occur and should be minimised in intensity, e.g. via a gradual tapering off of medication over a period of weeks or months.[71][72][73] A very small study of abrupt withdrawal of stimulants did suggest that withdrawal reactions are not typical. Nonetheless, withdrawal reactions may still occur in susceptible individuals.[74] The withdrawal or rebound symptoms of methylphenidate can include psychosis, depression, irritability and a temporary worsening of the original ADHD symptoms. Methylphenidate, due to its very short elimination half life, may be more prone to rebound effects than d-amphetamine.[25][75][76] Up to a third of children with ADHD experience a rebound effect when methylphenidate dose wears off.[77]